Why ADHD Medication Is Not Always Enough Part 1

PART 2: Why the Medication Isn't Enough (And How Treatment Response Reveals the Real Story)

Treatment Response as a Diagnostic Marker (The Part Most Clinicians Miss)

Stimulant response

SSRI or SNRI response

Combined formulation over time

Here's something that deserves wider recognition:

The way you respond to medication can actually help clarify whether your difficulties are primarily neurodevelopmental or primarily trauma-based.

Let me explain.

Scenario 1: Robust response to stimulants

Some people start methylphenidate or lisdexamfetamine and experience a clear, substantial improvement: focus sharpens, organisation improves, emotional regulation stabilises, irritability decreases. They feel like they've been given glasses for their brain.

This pattern suggests a predominantly neurodevelopmental aetiology—meaning the primary driver of their difficulties is dopaminergic and noradrenergic deficiency in the prefrontal cortex, the hallmark of ADHD. The medication is addressing the core neurobiological deficit, and the improvement is meaningful.

Scenario 2: Poor or worsening response to stimulants, but good response to SSRIs/SNRIs

Other people start stimulants and find they don't help much—or they actually feel worse. Increased anxiety. Emotional flatness. Agitation. Insomnia that outweighs any benefit.

But when they try an SSRI (selective serotonin reuptake inhibitor) or SNRI (serotonin-norepinephrine reuptake inhibitor), things improve: emotional regulation stabilises, dissociation decreases, hypervigilance lessens, sleep improves.

This pattern may indicate that their executive dysfunction and emotional dysregulation are more rooted in a trauma-based neurobiological response—where serotonergic dysregulation and a chronically hyperactive amygdala are the primary drivers, not dopamine deficiency. SSRIs are the proven first-line pharmacotherapy for PTSD in adults and improve core PTSD symptoms such as avoidance, numbing, and dissociation[28].

Scenario 3: Both (the most common)

The clinical reality is usually that it's both. You have neurodevelopmental ADHD and trauma-based dysregulation. The stimulant helps with focus and impulse control. The SSRI helps with emotional regulation and trauma symptoms. And psychotherapy helps you figure out who you actually are and what you actually want.

But the relative balance between neurodevelopmental and trauma-based contributions can sometimes be inferred from the treatment response, providing valuable diagnostic information that refines the formulation over time.

Notably, when ADHD is comorbid with depression, recent research has established that there is an increased risk of resistance to antidepressants if ADHD is not treated first[3]. This suggests a sequencing principle: addressing the neurodevelopmental substrate first may unmask the trauma-based components and allow them to respond to appropriate treatment.

The Accountability Part No One Wants to Hear

This is the part where I tell you something you probably don't want to hear, but that is absolutely essential:

No one can do this work for you.

Not your psychiatrist. Not your therapist. Not your partner, your parents, your friends. No medication, however effective, can teach you who you are.

The discovery of the authentic self, the willingness to set boundaries, to say no, to pursue what genuinely matters, to take accountability for your own actions rather than projecting blame onto others—these are the domains of psychotherapy. And you have to show up for them.

Multimodal treatment approaches encompassing psychoeducation, pharmacotherapy, and disorder-oriented psychotherapy are considered essential at any age[26][27]. Medication creates the neurobiological conditions for this work. It does not replace it.

This is not about blame. You didn't choose to be neurodivergent. You didn't choose the family you grew up in. You didn't choose the trauma. You didn't choose to develop a false self—it was a survival mechanism, and it worked.

But you do get to choose what happens next. And that choice requires accountability: the willingness to look honestly at your life, to grieve what was lost, to acknowledge the ways you've participated in your own suffering (through avoidance, through people-pleasing, through refusing to ask for what you need), and to commit to the difficult, slow, sometimes painful work of becoming real.

What Comes Next

In Part 3, we'll explore the neurodiversity-affirming paradigm that should underpin all of this work, the specific therapeutic modalities that are most effective for co-occurring ADHD and trauma, and the ultimate question: How do you build a meaningful life when you're finally living as yourself instead of as the mask?

This is hard work. But it's also the only work that actually sets you free.


If you're in Cork and ready to move beyond symptom management toward authentic self-discovery, contact our clinic for trauma-informed, neurodiversity-affirming psychotherapy.


Move beyond symptom management

If you're in Cork and ready to move beyond symptom management toward authentic self-discovery, contact our clinic for trauma-informed, neurodiversity-affirming psychotherapy.

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References

[1] Kooij, J.J.S., et al. (2015). Basic & Clinical Pharmacology & Toxicology, 116(4), 291-298.

[2] World Psychiatric Association (2008). ADHD in Adults.

[3] EPA Congress News, Nice, 2018.

[23] The lived experience of rejection sensitivity in ADHD. PLoS ONE, 2024.

[25] The impact of validation seeking on self-image and internalised stigma in adult ADHD. PLoS ONE, 2024.

[26][27] Friendship matters: An interview study with adolescents with ADHD. PLOS Mental Health, 2024.

[28] Posttraumatic Stress Disorder in Children. MEDBOX clinical guidelines.

[30] Bateman, A., & Fonagy, P. Mentalization-based therapies. Oxford Academic, 2016.

[31] The lived experience of rejection sensitivity in ADHD. PLoS ONE, 2024.


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